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A catalog of the mouse gut metagenome

Nature Biotechnology, ISSN: 1546-1696, Vol: 33, Issue: 10, Page: 1103-1108
2015
  • 356
    Citations
  • 0
    Usage
  • 673
    Captures
  • 3
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    356
    • Citation Indexes
      354
    • Patent Family Citations
      1
      • Patent Families
        1
    • Policy Citations
      1
      • Policy Citation
        1
  • Captures
    673
  • Mentions
    3
    • References
      2
      • Wikipedia
        2
    • Blog Mentions
      1
      • Blog
        1

Most Recent Blog

Similarity of the dog and human gut microbiomes in gene content and response to diet

My paper Similarity of the dog and human gut microbiomes in gene content and response to diet was published yesterday in Microbiome. It was a long time in the making (and almost a year in the review process: submitted 11 May 2017), but now it’s finally published! It has been picking up quite a bit of press, which is nice too. It’s open access, so everyone can read it, but here’s a basic summary: *

Article Description

We established a catalog of the mouse gut metagenome comprising ∼ 2.6 million nonredundant genes by sequencing DNA from fecal samples of 184 mice. To secure high microbiome diversity, we used mouse strains of diverse genetic backgrounds, from different providers, kept in different housing laboratories and fed either a low-fat or high-fat diet. Similar to the human gut microbiome, >99% of the cataloged genes are bacterial. We identified 541 metagenomic species and defined a core set of 26 metagenomic species found in 95% of the mice. The mouse gut microbiome is functionally similar to its human counterpart, with 95.2% of its Kyoto Encyclopedia of Genes and Genomes (KEGG) orthologous groups in common. However, only 4.0% of the mouse gut microbial genes were shared (95% identity, 90% coverage) with those of the human gut microbiome. This catalog provides a useful reference for future studies.

Bibliographic Details

Xiao, Liang; Feng, Qiang; Liang, Suisha; Sonne, Si Brask; Xia, Zhongkui; Qiu, Xinmin; Li, Xiaoping; Long, Hua; Zhang, Jianfeng; Zhang, Dongya; Liu, Chuan; Fang, Zhiwei; Chou, Joyce; Glanville, Jacob; Hao, Qin; Kotowska, Dorota; Colding, Camilla; Licht, Tine Rask; Wu, Donghai; Yu, Jun; Sung, Joseph Jao Yiu; Liang, Qiaoyi; Li, Junhua; Jia, Huijue; Lan, Zhou; Tremaroli, Valentina; Dworzynski, Piotr; Nielsen, H Bjørn; Bäckhed, Fredrik; Doré, Joël; Le Chatelier, Emmanuelle; Ehrlich, S Dusko; Lin, John C; Arumugam, Manimozhiyan; Wang, Jun; Madsen, Lise; Kristiansen, Karsten

Springer Science and Business Media LLC

Biochemistry, Genetics and Molecular Biology; Chemical Engineering; Immunology and Microbiology; Engineering

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