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Directing NGF's actions: It's a rap

Nature Cell Biology, ISSN: 1465-7392, Vol: 7, Issue: 4, Page: 338-339
2005
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Article Description

Epidermal growth factor and nerve growth factor (NGF) lead to significantly different temporal patterns of extracellular-signal-regulated kinase activation, and differential regulation of Ras and Rap1 have been implicated in mediating this temporal specificity. Now Sasagawa et al. derive a computational model that incorporates the known signalling interactions and identifies key points of regulation that control these processes.

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