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An Apollon vista of death and destruction

Nature Cell Biology, ISSN: 1465-7392, Vol: 6, Issue: 9, Page: 804-806
2004
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Proteins containing the BIR motif have been implicated as regulators of apoptosis and cell division. Apollon, an exceptionally large BIR-containing protein, inhibits apoptosis by targeting key cell death proteins for destruction by the ubiquitin-proteasome pathway. Now, deletion of apollon in the mouse has revealed a crucial function in cell division.

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