A pathway for phagosome maturation during engulfment of apoptotic cells
Nature Cell Biology, ISSN: 1465-7392, Vol: 10, Issue: 5, Page: 556-566
2008
- 225Citations
- 223Captures
- 1Mentions
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations225
- Citation Indexes225
- 225
- CrossRef205
- Captures223
- Readers223
- 223
- Mentions1
- References1
- Wikipedia1
Article Description
Removal of apoptotic cells is critical for the physiological well-being of the organism and defects in corpse removal have been linked to disease states. Genes regulating corpse recognition and internalization have been identified, but few molecules involved in the processing of internalized corpses are known. Through a combination of targeted and unbiased reverse genetic screens in Caenorhabditis elegans, and studies in mammalian cells, we have identified genes required for maturation of apoptotic-cell-containing phagosomes. We have further ordered these candidates, which include the GTPases RAB-5 and RAB-7 and the HOPS complex, into a coherent linear pathway for the maturation of apoptotic cells within phagosomes. In depth analysis of two additional candidate genes, the phosphatidylinositol 3 kinase (PI(3)K) vps-34 (A001762) and dyn-1/dynamin, showed an accumulation of internalized, but undegraded, corpses within abnormal Rab5-negative phagosomes. We ordered these candidates in our pathway, with DYN-1 functioning upstream of VPS-34 in the recruitment and/or retention of RAB-5 to the phagosome. Finally, we have also identified a previously undescribed biochemical complex containing Vps34, dynamin and Rab5, thus providing a mechanism for Rab5 recruitment to the nascent phagosome.
Bibliographic Details
10.1038/ncb1718; 10.3410/f.1108190.572723; 10.3410/f.1108190.564195; 10.3410/f.1108190.564450; 10.5167/uzh-16592
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=43049147117&origin=inward; http://dx.doi.org/10.1038/ncb1718; http://www.ncbi.nlm.nih.gov/pubmed/18425118; https://facultyopinions.com/prime/1108190#eval572723; http://dx.doi.org/10.3410/f.1108190.572723; https://www.nature.com/articles/ncb1718; https://facultyopinions.com/prime/1108190#eval564195; http://dx.doi.org/10.3410/f.1108190.564195; https://facultyopinions.com/prime/1108190#eval564450; http://dx.doi.org/10.3410/f.1108190.564450; https://www.zora.uzh.ch/id/eprint/16592; https://dx.doi.org/10.1038/ncb1718; http://dx.doi.org/10.5167/uzh-16592; https://dx.doi.org/10.5167/uzh-16592; https://www.zora.uzh.ch/id/eprint/16592/; http://f1000.com/1108190#eval572723; http://f1000.com/1108190#eval564195; https://www.zora.uzh.ch/id/eprint/16592/1/Kinchen_Pathway_V.pdf; http://f1000.com/1108190#eval564450; https://www.zora.uzh.ch/id/eprint/16592/8/Kinchen_Pathway_V.pdf
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