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Cyclin C surprises in tumour suppression

Nature Cell Biology, ISSN: 1476-4679, Vol: 16, Issue: 11, Page: 1031-1033
2014
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Review Description

Despite the importance of cyclins and cyclin-dependent kinases (Cdks) in the control of cell division, the physiological role of many of these regulators remains unknown. Cyclin C and its associated kinases Cdk3, Cdk8 and Cdk19 are now shown to function as tumour suppressors in haematopoietic malignancies by inhibiting the Notch1 pathway.

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