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Metabolic pathways promoting cancer cell survival and growth

Nature Cell Biology, ISSN: 1476-4679, Vol: 17, Issue: 4, Page: 351-359
2015
  • 1,123
    Citations
  • 0
    Usage
  • 1,294
    Captures
  • 5
    Mentions
  • 21
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    1,123
  • Captures
    1,294
  • Mentions
    5
    • News Mentions
      5
      • 5
  • Social Media
    21
    • Shares, Likes & Comments
      21
      • Facebook
        21

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Introduction Metabolic pathways play a vital role in providing cancer cells with energy, maintaining redox balance, and supplying the raw materials for biomacromolecule synthesis.1,2 Metabolic

Review Description

Activation of oncogenes and loss of tumour suppressors promote metabolic reprogramming in cancer, resulting in enhanced nutrient uptake to supply energetic and biosynthetic pathways. However, nutrient limitations within solid tumours may require that malignant cells exhibit metabolic flexibility to sustain growth and survival. Here, we highlight these adaptive mechanisms and also discuss emerging approaches to probe tumour metabolism in vivo and their potential to expand the metabolic repertoire of malignant cells even further.

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