PlumX Metrics
Embed PlumX Metrics

Hsf1 and Hsp90 orchestrate temperature-dependent global transcriptional remodelling and chromatin architecture in Candida albicans

Nature Communications, ISSN: 2041-1723, Vol: 7, Issue: 1, Page: 11704
2016
  • 76
    Citations
  • 0
    Usage
  • 112
    Captures
  • 0
    Mentions
  • 54
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    76
  • Captures
    112
  • Social Media
    54
    • Shares, Likes & Comments
      54
      • Facebook
        54

Article Description

Fever is a universal response to infection, and opportunistic pathogens such as Candida albicans have evolved complex circuitry to sense and respond to heat. Here we harness RNA-seq and ChIP-seq to discover that the heat shock transcription factor, Hsf1, binds distinct motifs in nucleosome-depleted promoter regions to regulate heat shock genes and genes involved in virulence in C. albicans. Consequently, heat shock increases C. albicans host cell adhesion, damage and virulence. Hsf1 activation depends upon the molecular chaperone Hsp90 under basal and heat shock conditions, but the effects are opposite and in part controlled at the level of Hsf1 expression and DNA binding. Finally, we demonstrate that Hsp90 regulates global transcription programs by modulating nucleosome levels at promoters of stress-responsive genes. Thus, we describe a mechanism by which C. albicans responds to temperature via Hsf1 and Hsp90 to orchestrate gene expression and chromatin architecture, thereby enabling thermal adaptation and virulence.

Bibliographic Details

Leach, Michelle D.; Farrer, Rhys A.; Tan, Kaeling; Miao, Zhengqiang; Walker, Louise A.; Cuomo, Christina A.; Wheeler, Robert T.; Brown, Alistair J. P.; Wong, Koon Ho; Cowen, Leah E.

Springer Science and Business Media LLC

Chemistry; Biochemistry, Genetics and Molecular Biology; Physics and Astronomy

Provide Feedback

Have ideas for a new metric? Would you like to see something else here?Let us know