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Borealin dimerization mediates optimal CPC checkpoint function by enhancing localization to centromeres and kinetochores

Nature Communications, ISSN: 2041-1723, Vol: 6, Issue: 1, Page: 6775
2015
  • 50
    Citations
  • 0
    Usage
  • 72
    Captures
  • 0
    Mentions
  • 13
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    50
  • Captures
    72
  • Social Media
    13
    • Shares, Likes & Comments
      13
      • Facebook
        13

Article Description

The chromosomal passenger complex (CPC) localizes to centromeres where it activates the mitotic checkpoint in response to inappropriate inter-kinetochore tension. This error correction function is essential for proper chromosome segregation. Here we define several critical features of CPC localization and function. First, the Borealin dimerization domain suppresses dynamic exchange at the centromere to allow optimal CPC function. Second, Borealin dimerization is essential to target a subpopulation of CPC proximal to the kinetochore when the mitotic spindle is disrupted. This subpopulation is also needed for full CPC checkpoint function. The existence of a pool of CPC at the kinetochore suggests that error correction is more complicated than predicted from the Aurora B phosphorylation gradient model. Finally, Haspin kinase plays a key role in maintaining the slowly exchanging centromere Borealin pool, while Aurora B and Mps1 play minimal roles in maintaining CPC localization once cells are in mitosis.

Bibliographic Details

Bekier, Michael E; Mazur, Travis; Rashid, Maisha S; Taylor, William R

Springer Science and Business Media LLC

Chemistry; Biochemistry, Genetics and Molecular Biology; Physics and Astronomy

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