Eomesodermin-expressing T-helper cells are essential for chronic neuroinflammation
Nature Communications, ISSN: 2041-1723, Vol: 6, Issue: 1, Page: 8437
2015
- 105Citations
- 102Captures
- 1Mentions
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations105
- Citation Indexes104
- 104
- CrossRef73
- Patent Family Citations1
- Patent Families1
- Captures102
- Readers102
- 102
- Mentions1
- Blog Mentions1
- Blog1
Most Recent Blog
T cells for secondary progressive MS
Takashi Yamamura, Ben J.E. Raveney, Shinji Oki Study of eomesodermin-expressing CD4+ T cells sheds new light on the pathogenesis of secondary progressive multiple sclerosis In the pathology of multiple sclerosis (MS), T helper type 1 (Th1) cells secreting interferon-γ and Th17 cells producing interleukin-17 are linked with acute inflammation in the relapsing–remitting form of MS. Supportive of thi
Article Description
Development of acute experimental autoimmune encephalomyelitis (EAE) depends on Th17 cells expressing the nuclear factor NR4A2. However, in mice lacking NR4A2 in T cells, a late-onset disease is still inducible, despite a great reduction in acute inflammation. We here reveal that development of this late onset disease depends on cytotoxic T-cell-like CD4 T cells expressing the T-box transcription factor Eomesodermin (Eomes). T-cell-specific deletion of the Eomes gene remarkably ameliorates the late-onset EAE. Strikingly, similar Eomes CD4 T cells are increased in the peripheral blood and cerebrospinal fluid from patients in a progressive state of multiple sclerosis. Collective data indicate an involvement of granzyme B and protease-activated receptor-1 in the neuroinflammation mediated by Eomes CD4 T cells.
Bibliographic Details
Springer Science and Business Media LLC
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