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Systematic analysis of telomere length and somatic alterations in 31 cancer types

Nature Genetics, ISSN: 1546-1718, Vol: 49, Issue: 3, Page: 349-357
2017
  • 447
    Citations
  • 0
    Usage
  • 563
    Captures
  • 4
    Mentions
  • 9
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    447
    • Citation Indexes
      445
    • Patent Family Citations
      1
      • Patent Families
        1
    • Policy Citations
      1
      • Policy Citation
        1
  • Captures
    563
  • Mentions
    4
    • News Mentions
      4
      • News
        4
  • Social Media
    9
    • Shares, Likes & Comments
      9
      • Facebook
        9

Most Recent News

Targeting Telomere Dynamics as an Effective Approach for the Development of Cancer Therapeutics

Introduction Telomere is a protective structure located at the end of the linear chromosome of eukaryotes, which is made up of tandem repetitive DNA sequences

Article Description

Cancer cells survive cellular crisis through telomere maintenance mechanisms. We report telomere lengths in 18,430 samples, including tumors and non-neoplastic samples, across 31 cancer types. Telomeres were shorter in tumors than in normal tissues and longer in sarcomas and gliomas than in other cancers. Among 6,835 cancers, 73% expressed telomerase reverse transcriptase (TERT), which was associated with TERT point mutations, rearrangements, DNA amplifications and transcript fusions and predictive of telomerase activity. TERT promoter methylation provided an additional deregulatory TERT expression mechanism. Five percent of cases, characterized by undetectable TERT expression and alterations in ATRX or DAXX, demonstrated elongated telomeres and increased telomeric repeat-containing RNA (TERRA). The remaining 22% of tumors neither expressed TERT nor harbored alterations in ATRX or DAXX. In this group, telomere length positively correlated with TP53 and RB1 mutations. Our analysis integrates TERT abnormalities, telomerase activity and genomic alterations with telomere length in cancer.

Bibliographic Details

Barthel, Floris P; Wei, Wei; Tang, Ming; Martinez-Ledesma, Emmanuel; Hu, Xin; Amin, Samirkumar B; Akdemir, Kadir C; Seth, Sahil; Song, Xingzhi; Wang, Qianghu; Lichtenberg, Tara; Hu, Jian; Zhang, Jianhua; Zheng, Siyuan; Verhaak, Roel G W

Springer Science and Business Media LLC

Biochemistry, Genetics and Molecular Biology

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