A critical function for TGF-β signaling in the development of natural CD4CD25Foxp3 regulatory T cells
Nature Immunology, ISSN: 1529-2908, Vol: 9, Issue: 6, Page: 632-640
2008
- 483Citations
- 294Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations483
- Citation Indexes483
- 483
- CrossRef434
- Captures294
- Readers294
- 294
Article Description
The molecular mechanisms directing the development of 'natural' CD4CD25Foxp3 regulatory T cells (T cells) in the thymus are not thoroughly understood. We show here that conditional deletion of transforming growth factor-β receptor I (TβRI) in T cells blocked the appearance of CD4CD25Foxp3 thymocytes at postnatal days 3-5. Paradoxically, however, beginning 1 week after birth, the same TβRI-mutant mice showed accelerated expansion of thymic CD4CD25Foxp3 populations. This rapid recovery of Foxp3 thymocytes was attributable mainly to overproduction of and heightened responsiveness to interleukin 2, as genetic ablation of interleukin 2 in TβRI-mutant mice resulted in a complete absence of CD4CD25Foxp3 cells from the thymus and periphery. Thus, transforming growth factor-β signaling is critical to the thymic development of natural CD4CD25Foxp3 T cells.
Bibliographic Details
Springer Science and Business Media LLC
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