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Critical role for the chemokine receptor CXCR6 in NK cell-mediated antigen-specific memory of haptens and viruses

Nature Immunology, ISSN: 1529-2908, Vol: 11, Issue: 12, Page: 1127-1135
2010
  • 573
    Citations
  • 0
    Usage
  • 539
    Captures
  • 1
    Mentions
  • 19
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    573
  • Captures
    539
  • Mentions
    1
    • News Mentions
      1
      • 1
  • Social Media
    19
    • Shares, Likes & Comments
      19
      • Facebook
        19

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Article Description

Hepatic natural killer (NK) cells mediate antigen-specific contact hypersensitivity (CHS) in mice deficient in T cells and B cells. We report here that hepatic NK cells, but not splenic or naive NK cells, also developed specific memory of vaccines containing antigens from influenza, vesicular stomatitis virus (VSV) or human immunodeficiency virus type 1 (HIV-1). Adoptive transfer of virus-sensitized NK cells into naive recipient mice enhanced the survival of the mice after lethal challenge with the sensitizing virus but not after lethal challenge with a different virus. NK cell memory of haptens and viruses depended on CXCR6, a chemokine receptor on hepatic NK cells that was required for the persistence of memory NK cells but not for antigen recognition. Thus, hepatic NK cells can develop adaptive immunity to structurally diverse antigens, an activity that requires NK cell-expressed CXCR6. © 2010 Nature America, Inc. All rights reserved.

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