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Natural killer cell memory

Nature Immunology, ISSN: 1529-2908, Vol: 12, Issue: 6, Page: 500-508
2011
  • 203
    Citations
  • 0
    Usage
  • 337
    Captures
  • 1
    Mentions
  • 5
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    203
  • Captures
    337
  • Mentions
    1
    • References
      1
      • 1
  • Social Media
    5
    • Shares, Likes & Comments
      5
      • Facebook
        5

Review Description

Natural killer (NK) cells are bone marrow-"derived granular lymphocytes that have a key role in immune defense against viral and bacterial infections and malignancies. NK cells are traditionally defined as cells of the innate immune response because they lack RAG recombinase-"dependent clonal antigen receptors. However, evidence suggests that specific subsets of mouse NK cells can nevertheless develop long-lived and highly specific memory to a variety of antigens. Here we review published evidence of NK cell-"mediated, RAG-independent adaptive immunity. We also compare and contrast candidate mechanisms for mammalian NK cell memory and antigen recognition with other examples of RAG-independent pathways that generate antigen receptor diversity in non-mammalian species and discuss NK cell memory in the context of lymphocyte evolution. © 2011 Nature America, Inc. All rights reserved.

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