Activation of caspase-1 by the NLRP3 inflammasome regulates the NADPH oxidase NOX2 to control phagosome function
Nature Immunology, ISSN: 1529-2908, Vol: 14, Issue: 6, Page: 543-553
2013
- 174Citations
- 257Captures
- 3Mentions
Metric Options: CountsSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations174
- Citation Indexes174
- 174
- CrossRef157
- Captures257
- Readers257
- 256
- Mentions3
- References3
- Wikipedia3
Article Description
Phagocytosis is a fundamental cellular process that is pivotal for immunity as it coordinates microbial killing, innate immune activation and antigen presentation. An essential step in this process is phagosome acidification, which regulates many functions of these organelles that allow phagosomes to participate in processes that are essential to both innate and adaptive immunity. Here we report that acidification of phagosomes containing Gram-positive bacteria is regulated by the NLRP3 inflammasome and caspase-1. Active caspase-1 accumulates on phagosomes and acts locally to control the pH by modulating buffering by the NADPH oxidase NOX2. These data provide insight into a mechanism by which innate immune signals can modify cellular defenses and establish a new function for the NLRP3 inflammasome and caspase-1 in host defense. © 2013 Nature America, Inc. All rights reserved.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84878245034&origin=inward; http://dx.doi.org/10.1038/ni.2595; http://www.ncbi.nlm.nih.gov/pubmed/23644505; https://www.nature.com/articles/ni.2595; https://facultyopinions.com/prime/718009510#eval793482677; http://dx.doi.org/10.3410/f.718009510.793482677; https://facultyopinions.com/prime/718009510#eval793476569; http://dx.doi.org/10.3410/f.718009510.793476569; https://dx.doi.org/10.1038/ni.2595
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