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Activation of caspase-1 by the NLRP3 inflammasome regulates the NADPH oxidase NOX2 to control phagosome function

Nature Immunology, ISSN: 1529-2908, Vol: 14, Issue: 6, Page: 543-553
2013
  • 174
    Citations
  • 0
    Usage
  • 257
    Captures
  • 3
    Mentions
  • 11
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    174
  • Captures
    257
  • Mentions
    3
    • References
      3
      • Wikipedia
        3
  • Social Media
    11
    • Shares, Likes & Comments
      11
      • Facebook
        11

Article Description

Phagocytosis is a fundamental cellular process that is pivotal for immunity as it coordinates microbial killing, innate immune activation and antigen presentation. An essential step in this process is phagosome acidification, which regulates many functions of these organelles that allow phagosomes to participate in processes that are essential to both innate and adaptive immunity. Here we report that acidification of phagosomes containing Gram-positive bacteria is regulated by the NLRP3 inflammasome and caspase-1. Active caspase-1 accumulates on phagosomes and acts locally to control the pH by modulating buffering by the NADPH oxidase NOX2. These data provide insight into a mechanism by which innate immune signals can modify cellular defenses and establish a new function for the NLRP3 inflammasome and caspase-1 in host defense. © 2013 Nature America, Inc. All rights reserved.

Bibliographic Details

Sokolovska, Anna; Becker, Christine E; Ip, W K Eddie; Rathinam, Vijay A K; Brudner, Matthew; Paquette, Nicholas; Tanne, Antoine; Vanaja, Sivapriya K; Moore, Kathryn J; Fitzgerald, Katherine A; Lacy-Hulbert, Adam; Stuart, Lynda M

Springer Science and Business Media LLC

Medicine; Immunology and Microbiology

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