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From prenatal genomic diagnosis to fetal personalized medicine: Progress and challenges

Nature Medicine, ISSN: 1078-8956, Vol: 18, Issue: 7, Page: 1041-1051
2012
  • 118
    Citations
  • 0
    Usage
  • 217
    Captures
  • 2
    Mentions
  • 9
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    118
  • Captures
    217
  • Mentions
    2
    • References
      2
      • Wikipedia
        2
  • Social Media
    9
    • Shares, Likes & Comments
      9
      • Facebook
        9

Review Description

Thus far, the focus of personalized medicine has been the prevention and treatment of conditions that affect adults. Although advances in genetic technology have been applied more frequently to prenatal diagnosis than to fetal treatment, genetic and genomic information is beginning to influence pregnancy management. Recent developments in sequencing the fetal genome combined with progress in understanding fetal physiology using gene expression arrays indicate that we could have the technical capabilities to apply an individualized medicine approach to the fetus. Here I review recent advances in prenatal genetic diagnostics, the challenges associated with these new technologies and how the information derived from them can be used to advance fetal care. Historically, the goal of prenatal diagnosis has been to provide an informed choice to prospective parents. We are now at a point where that goal can and should be expanded to incorporate genetic, genomic and transcriptomic data to develop new approaches to fetal treatment. © 2012 Nature America, Inc. All rights reserved.

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