PlumX Metrics
Embed PlumX Metrics

Long-term restoration of immunity against Epstein-Barr virus infection by adoptive transfer of gene-modified virus-specific T lymphocytes

Nature Medicine, ISSN: 1078-8956, Vol: 2, Issue: 5, Page: 551-555
1996
  • 733
    Citations
  • 0
    Usage
  • 99
    Captures
  • 1
    Mentions
  • 9
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    733
    • Citation Indexes
      728
    • Patent Family Citations
      4
      • Patent Families
        4
    • Policy Citations
      1
      • Policy Citation
        1
  • Captures
    99
  • Mentions
    1
    • News Mentions
      1
      • News
        1
  • Social Media
    9
    • Shares, Likes & Comments
      9
      • Facebook
        9

Most Recent News

Cellular therapies for solid cancer: clinical experience, challenges and future revolution

  Overview Immunotherapy has now emerged as the next frontier in cancer treatment. In 1891, William Coley first established the concept of harnessing the immune

Article Description

Adoptive transfer of antigen-specific cytotoxic T lymphocytes (CTLs) offers safe and effective therapy for certain viral infections and could prove useful in the eradication of tumor cells. Whether or not the infused T cells persist for extended periods, retaining their ability to expand in response to antigenic stimulation, is not known. We now report long-term detection of gene-marked Epstein-Barr virus (EBV)-specific CTLs in immunocompromised patients at risk for the development of EBV lymphoproliferative disease. Infusions of CTLs not only restored cellular immune responses against EBV, but also established populations of CTL precursors that could respond to in vivo or ex vivo challenge with the virus for as long as 18 months. Our findings support wider use of antigen-specific CTLs in adoptive immunotherapy.

Bibliographic Details

Helen E. Heslop; Catherine Y.C. Ng; Congfen Li; Colton A. Smith; Susan K. Loftin; Robert A. Krance; Malcolm K. Brenner; Cliona M. Rooney

Springer Science and Business Media LLC

Biochemistry, Genetics and Molecular Biology

Provide Feedback

Have ideas for a new metric? Would you like to see something else here?Let us know