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Nanofibrous hollow microspheres self-assembled from star-shaped polymers as injectable cell carriers for knee repair

Nature Materials, ISSN: 1476-4660, Vol: 10, Issue: 5, Page: 398-406
2011
  • 367
    Citations
  • 0
    Usage
  • 283
    Captures
  • 3
    Mentions
  • 13
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    367
  • Captures
    283
  • Mentions
    3
    • References
      3
      • Wikipedia
        3
  • Social Media
    13
    • Shares, Likes & Comments
      13
      • Facebook
        13

Article Description

To repair complexly shaped tissue defects, an injectable cell carrier is desirable to achieve an accurate fit and to minimize surgical intervention. However, the injectable carriers available at present have limitations, and are not used clinically for cartilage regeneration. Here, we report nanofibrous hollow microspheres self-assembled from star-shaped biodegradable polymers as an injectable cell carrier. The nanofibrous hollow microspheres, integrating the extracellular-matrix-mimicking architecture with a highly porous injectable form, were shown to efficiently accommodate cells and enhance cartilage regeneration, compared with control microspheres. The nanofibrous hollow microspheres also supported a significantly larger amount of, and higher-quality, cartilage regeneration than the chondrocytes-alone group in an ectopic implantation model. In a critical-size rabbit osteochondral defect-repair model, the nanofibrous hollow microspheres/chondrocytes group achieved substantially better cartilage repair than the chondrocytes-alone group that simulates the clinically available autologous chondrocyte implantation procedure. These results indicate that the nanofibrous hollow microspheres are an excellent injectable cell carrier for cartilage regeneration. © 2011 Macmillan Publishers Limited. All rights reserved.

Bibliographic Details

Liu, Xiaohua; Jin, Xiaobing; Ma, Peter X

Springer Science and Business Media LLC

Chemistry; Materials Science; Physics and Astronomy; Engineering

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