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β-amyloid disrupts human NREM slow waves and related hippocampus-dependent memory consolidation

Nature Neuroscience, ISSN: 1546-1726, Vol: 18, Issue: 7, Page: 1051-1057
2015
  • 415
    Citations
  • 0
    Usage
  • 738
    Captures
  • 43
    Mentions
  • 14
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    415
  • Captures
    738
  • Mentions
    43
    • News Mentions
      38
      • News
        38
    • Blog Mentions
      4
      • Blog
        4
    • References
      1
      • Wikipedia
        1
  • Social Media
    14
    • Shares, Likes & Comments
      14
      • Facebook
        14

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Article Description

Independent evidence associates β-amyloid pathology with both non-rapid eye movement (NREM) sleep disruption and memory impairment in older adults. However, whether the influence of β-amyloid pathology on hippocampus-dependent memory is, in part, driven by impairments of NREM slow wave activity (SWA) and associated overnight memory consolidation is unknown. Here we show that β-amyloid burden in medial prefrontal cortex (mPFC) correlates significantly with the severity of impairment in NREM SWA generation. Moreover, reduced NREM SWA generation was further associated with impaired overnight memory consolidation and impoverished hippocampal-neocortical memory transformation. Furthermore, structural equation models revealed that the association between mPFC β-amyloid pathology and impaired hippocampus-dependent memory consolidation was not direct, but instead statistically depended on the intermediary factor of diminished NREM SWA. By linking β-amyloid pathology with impaired NREM SWA, these data implicate sleep disruption as a mechanistic pathway through which β-amyloid pathology may contribute to hippocampus-dependent cognitive decline in the elderly.

Bibliographic Details

Mander, Bryce A; Marks, Shawn M; Vogel, Jacob W; Rao, Vikram; Lu, Brandon; Saletin, Jared M; Ancoli-Israel, Sonia; Jagust, William J; Walker, Matthew P

Springer Science and Business Media LLC

Neuroscience

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