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Biomolecular coronas provide the biological identity of nanosized materials

Nature Nanotechnology, ISSN: 1748-3395, Vol: 7, Issue: 12, Page: 779-786
2012
  • 2,267
    Citations
  • 0
    Usage
  • 1,665
    Captures
  • 2
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    2,267
    • Citation Indexes
      2,248
    • Policy Citations
      18
      • Policy Citation
        18
    • Patent Family Citations
      1
      • Patent Families
        1
  • Captures
    1,665
  • Mentions
    2
    • News Mentions
      2
      • News
        2

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Article Description

The search for understanding the interactions of nanosized materials with living organisms is leading to the rapid development of key applications, including improved drug delivery by targeting nanoparticles, and resolution of the potential threat of nanotechnological devices to organisms and the environment. Unless they are specifically designed to avoid it, nanoparticles in contact with biological fluids are rapidly covered by a selected group of biomolecules to form a corona that interacts with biological systems. Here we review the basic concept of the nanoparticle corona and its structure and composition, and highlight how the properties of the corona may be linked to its biological impacts. We conclude with a critical assessment of the key problems that need to be resolved in the near future. Copyright © 2012 Macmillan Publishers Limited.

Bibliographic Details

Monopoli, Marco P.; Åberg, Christoffer; Salvati, Anna; Dawson, Kenneth A.

Springer Science and Business Media LLC

Chemical Engineering; Physics and Astronomy; Engineering; Materials Science

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