Collagen-induced arthritis
Nature Protocols, ISSN: 1754-2189, Vol: 2, Issue: 5, Page: 1269-1275
2007
- 1,108Citations
- 925Captures
- 5Mentions
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations1,108
- Citation Indexes1,104
- 1,104
- CrossRef864
- Patent Family Citations4
- Patent Families4
- Captures925
- Readers925
- 925
- Mentions5
- News Mentions2
- News2
- References2
- Wikipedia2
- Blog Mentions1
- Blog1
Most Recent Blog
The Minor Phytocannabinoid Delta-8-Tetrahydrocannabinol Attenuates Collagen-Induced Arthritic Inflammation and Pain-Depressed Behaviors [Special Section: Cannabinoid Signaling in Human Health and Disease]
Research ArticleSpecial Section: Cannabinoid Signaling in Human Health and Disease Open Access The Minor Phytocannabinoid Delta-8-Tetrahydrocannabinol Attenuates Collagen-Induced Arthritic Inflammation and Pain-Depressed Behaviors S. Olivia
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Introduction Rheumatoid arthritis (RA) is a persistent and systemic autoimmune disease characterized by synovial inflammation, destruction of bone and cartilage, and invasion of inflammatory cells.1
Article Description
The collagen-induced arthritis (CIA) mouse model is the most commonly studied autoimmune model of rheumatoid arthritis. Autoimmune arthritis is induced in this model by immunization with an emulsion of complete Freund's adjuvant and type II collagen (CII). This protocol describes the steps necessary for acquisition, handling and preparation of CII, as well as selection of mouse strains, proper immunization technique and evaluation of the arthritis incidence and severity. Typically, the first signs of arthritis appear in this model 21-28 days after immunization, and identification of the arthritic limbs is not difficult. Using the protocol described, the investigator should be able to reproducibly induce a high incidence of CIA in various strains of genetically susceptible mice as well as learn how to critically evaluate the pathology of the disease. The total time for the preparation of reagents and the immunization of ten mice is about 1.5 h.
Bibliographic Details
Springer Science and Business Media LLC
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