PlumX Metrics
Embed PlumX Metrics

Tissue, cell and stage specificity of (epi)mutations in cancers

Nature Reviews Cancer, ISSN: 1474-175X, Vol: 5, Issue: 8, Page: 649-655
2005
  • 65
    Citations
  • 0
    Usage
  • 88
    Captures
  • 0
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

Review Description

Most (epi)mutations in cancers are specific to particular tumours or occur at specific stages of development, cell differentiation or tumorigenesis. Simple molecular mechanisms, such as tissue-restricted gene expression, seem to explain these associations only in rare cases. Instead, the specificity of (epi)mutations is probably due to the selection of a restricted spectrum of genetic changes by the cellular environment. In some cases, the resulting functional defects might be constrained to be neither too strong nor too weak for tumour growth to occur; that is, they lie within a 'window' that is permissive for tumorigenesis.

Bibliographic Details

Oliver M. Sieber; Simon R. Tomlinson; Ian P. M. Tomlinson

Springer Science and Business Media LLC

Medicine; Biochemistry, Genetics and Molecular Biology

Provide Feedback

Have ideas for a new metric? Would you like to see something else here?Let us know