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Advances in sarcoma genomics and new therapeutic targets

Nature Reviews Cancer, ISSN: 1474-175X, Vol: 11, Issue: 8, Page: 541-557
2011
  • 332
    Citations
  • 0
    Usage
  • 427
    Captures
  • 0
    Mentions
  • 5
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    332
  • Captures
    427
  • Social Media
    5
    • Shares, Likes & Comments
      5
      • Facebook
        5

Review Description

Increasingly, human mesenchymal malignancies are being classified by the abnormalities that drive their pathogenesis. Although many of these aberrations are highly prevalent within particular sarcoma subtypes, few are currently targeted therapeutically. Indeed, most subtypes of sarcoma are still treated with traditional therapeutic modalities, and in many cases sarcomas are resistant to adjuvant therapies. In this Review, we discuss the core molecular determinants of sarcomagenesis and emphasize the emerging genomic and functional genetic approaches that, coupled with novel therapeutic strategies, have the potential to transform the care of patients with sarcoma. © 2011 Macmillan Publishers Limited. All rights reserved.

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