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Targeting IL-1 in inflammatory disease: New opportunities for therapeutic intervention

Nature Reviews Drug Discovery, ISSN: 1474-1776, Vol: 3, Issue: 4, Page: 330-339
2004
  • 206
    Citations
  • 0
    Usage
  • 146
    Captures
  • 2
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    206
  • Captures
    146
  • Mentions
    2
    • News Mentions
      2
      • News
        2

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ETV5 is a Putative Differentially Expressed Transcription Factor of Interleukin 1β Under Neuroinflammatory Conditions in Murine Cerebellum

Key words Neuroinflammation, Neurodegeneration, Transcription factors, Gene expression analysis, RT-PCR, RNA-seq analysis INTRODUCTION The inflammation of brain and spinal cord, together constituting our central nervous

Review Description

The cytokine interleukin-1 (IL-1) is important in many human diseases, and drives a wide range of inflammatory responses in a number of cell types. Biological agents that target IL-1 neutralization have shown efficacy in patients with rheumatoid arthritis. Recently, new classes of compounds that target IL-1 production or processing, or regulatory steps on the IL-1 pathway, are being investigated as new drugs for the management of inflammatory disease. Such compounds will have wide utility in numerous inflammatory conditions.

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