Targeting proteinase-activated receptors: Therapeutic potential and challenges
Nature Reviews Drug Discovery, ISSN: 1474-1776, Vol: 11, Issue: 1, Page: 69-86
2012
- 272Citations
- 2Usage
- 298Captures
- 1Mentions
Metric Options: CountsSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations272
- Citation Indexes270
- CrossRef270
- 269
- Patent Family Citations2
- Patent Families2
- Usage2
- Abstract Views2
- Captures298
- Readers298
- 298
- Mentions1
- References1
- Wikipedia1
Review Description
Proteinase-activated receptors (PARs), a family of four seven-transmembrane G protein-coupled receptors, act as targets for signalling by various proteolytic enzymes. PARs are characterized by a unique activation mechanism involving the proteolytic unmasking of a tethered ligand that stimulates the receptor. Given the emerging roles of these receptors in cancer as well as in disorders of the cardiovascular, musculoskeletal, gastrointestinal, respiratory and central nervous system, PARs have become attractive targets for the development of novel therapeutics. In this Review we summarize the mechanisms by which PARs modulate cell function and the roles they can have in physiology and diseases. Furthermore, we provide an overview of possible strategies for developing PAR antagonists. © 2012 Macmillan Publishers Limited. All rights reserved.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84855376225&origin=inward; http://dx.doi.org/10.1038/nrd3615; http://www.ncbi.nlm.nih.gov/pubmed/22212680; https://www.nature.com/articles/nrd3615; https://ir.lib.uwo.ca/physpharmpub/173; https://ir.lib.uwo.ca/cgi/viewcontent.cgi?article=1200&context=physpharmpub; https://dx.doi.org/10.1038/nrd3615
Springer Science and Business Media LLC
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