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Modulation of oxidative stress as an anticancer strategy

Nature Reviews Drug Discovery, ISSN: 1474-1776, Vol: 12, Issue: 12, Page: 931-947
2013
  • 2,833
    Citations
  • 0
    Usage
  • 1,911
    Captures
  • 2
    Mentions
  • 13
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    2,833
    • Citation Indexes
      2,819
    • Patent Family Citations
      10
      • Patent Families
        10
    • Policy Citations
      4
      • Policy Citation
        4
  • Captures
    1,911
  • Mentions
    2
    • News Mentions
      1
      • News
        1
    • References
      1
      • Wikipedia
        1
  • Social Media
    13
    • Shares, Likes & Comments
      13
      • Facebook
        13

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Review Description

The regulation of oxidative stress is an important factor in both tumour development and responses to anticancer therapies. Many signalling pathways that are linked to tumorigenesis can also regulate the metabolism of reactive oxygen species (ROS) through direct or indirect mechanisms. High ROS levels are generally detrimental to cells, and the redox status of cancer cells usually differs from that of normal cells. Because of metabolic and signalling aberrations, cancer cells exhibit elevated ROS levels. The observation that this is balanced by an increased antioxidant capacity suggests that high ROS levels may constitute a barrier to tumorigenesis. However, ROS can also promote tumour formation by inducing DNA mutations and pro-oncogenic signalling pathways. These contradictory effects have important implications for potential anticancer strategies that aim to modulate levels of ROS. In this Review, we address the controversial role of ROS in tumour development and in responses to anticancer therapies, and elaborate on the idea that targeting the antioxidant capacity of tumour cells can have a positive therapeutic impact. © 2013 Macmillan Publishers Limited.

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