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Metabonomics: A platform for studying drug toxicity and gene function

Nature Reviews Drug Discovery, ISSN: 1474-1776, Vol: 1, Issue: 2, Page: 153-161
2002
  • 1,838
    Citations
  • 0
    Usage
  • 770
    Captures
  • 4
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    1,838
    • Citation Indexes
      1,834
    • Policy Citations
      3
      • Policy Citation
        3
    • Clinical Citations
      1
      • PubMed Guidelines
        1
  • Captures
    770
  • Mentions
    4
    • References
      4
      • Wikipedia
        4

Review Description

The later that a molecule or molecular class is lost from the drug development pipeline, the higher the financial cost. Minimizing attrition is therefore one of the most important aims of a pharmaceutical discovery programme. Novel technologies that increase the probability of making the right choice early save resources, and promote safety, efficacy and profitability. Metabonomics is a systems approach for studying in vivo metabolic profiles, which promises to provide information on drug toxicity, disease processes and gene function at several stages in the discovery-and-development process. © 2002 Macmillan Magazines Ltd.

Bibliographic Details

Nicholson, Jeremy K.; Connelly, John; Lindon, John C.; Holmes, Elaine

Springer Science and Business Media LLC

Pharmacology, Toxicology and Pharmaceutics

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