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Metabolism and regulation of canonical histone mRNAs: Life without a poly(A) tail

Nature Reviews Genetics, ISSN: 1471-0056, Vol: 9, Issue: 11, Page: 843-854
2008
  • 568
    Citations
  • 0
    Usage
  • 729
    Captures
  • 9
    Mentions
  • 3
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    568
  • Captures
    729
  • Mentions
    9
    • References
      8
      • Wikipedia
        8
    • News Mentions
      1
      • News
        1
  • Social Media
    3
    • Shares, Likes & Comments
      3
      • Facebook
        3

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Review Description

The canonical histone proteins are encoded by replication-dependent genes and must rapidly reach high levels of expression during S phase. In metazoans the genes that encode these proteins produce mRNAs that, instead of being polyadenylated, contain a unique 3′ end structure. By contrast, the synthesis of the variant, replication-independent histones, which are encoded by polyadenylated mRNAs, persists outside of S phase. Accurate positioning of both histone types in chromatin is essential for proper transcriptional regulation, the demarcation of heterochromatic boundaries and the epigenetic inheritance of gene expression patterns. Recent results suggest that the coordinated synthesis of replication-dependent and variant histone mRNAs is achieved by signals that affect formation of the 3′ end of the replication-dependent histone mRNAs. © 2008 Macmillan Publishers Limited. All rights reserved.

Bibliographic Details

William F. Marzluff; Eric J. Wagner; Robert J. Duronio

Springer Science and Business Media LLC

Biochemistry, Genetics and Molecular Biology; Medicine

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