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Immune functions encoded by the natural killer gene complex

Nature Reviews Immunology, ISSN: 1474-1733, Vol: 3, Issue: 4, Page: 304-316
2003
  • 497
    Citations
  • 0
    Usage
  • 273
    Captures
  • 0
    Mentions
  • 0
    Social Media
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Metrics Details

  • Citations
    497
  • Captures
    273

Review Description

There has been marked progress in our understanding of the role of natural killer (NK) cells in immune responses, mainly due to the identification of NK-cell receptors and their ligands. The genes encoding many NK-cell receptors are located in the NK-gene complex (NKC). Here, we review the properties of NKC-encoded receptors, and provide a genomic and conceptual framework for an insight into NK-cell function and biology.

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