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A forward-genetic approach for analysis of the immune system

Nature Reviews Immunology, ISSN: 1474-1733, Vol: 3, Issue: 6, Page: 463-471
2003
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Base-editing mutagenesis maps alleles to tune human T cell functions

Nature, Published online: 13 December 2023; doi:10.1038/s41586-023-06835-6 Massive-scale mutational screening across 385 genes reveals a wide spectrum of alleles that govern tunable T cell functions, including cytokine production and cytotoxicity.

Review Description

The completion of the genome sequences of both humans and mice challenges biologists to determine gene function on a vast, whole-organism scale. Both phenotype-based ('forward') and gene-based ('reverse') strategies are being developed to approach this issue. Forward-genetic approaches, however, provide the unique ability of assigning function to genes in an unbiased, global manner that is independent of previous assumptions about gene function. In this article, we compare various genetic technologies for their potential role in dissecting immune-system development and function, with particular emphasis on the worldwide efforts that use chemical mutagenesis as a forward-genetic strategy.

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