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Mechanisms and functions for the duration of intercellular contacts made by lymphocytes

Nature Reviews Immunology, ISSN: 1474-1733, Vol: 9, Issue: 8, Page: 543-555
2009
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Review Description

Communication across intercellular contacts is central to establishing appropriate innate and adaptive immune responses. Recent imaging of lymphocyte interactions suggests that a complex orchestration of cell-cell contact times is a key correlate to establishing appropriate immune responses. Here I review the molecular and cellular processes that influence the duration of intercellular contacts, including integrin activation and dynamic changes in membrane morphology. I discuss how these processes can be regulated, for example, by the balance of activating and inhibitory receptor signals, and how they can establish the appropriate outcome for individual cell-cell interactions. © 2009 Macmillan Publishers Limited. All rights reserved.

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