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Regulation of microRNA biogenesis

Nature Reviews Molecular Cell Biology, ISSN: 1471-0080, Vol: 15, Issue: 8, Page: 509-524
2014
  • 4,416
    Citations
  • 0
    Usage
  • 4,827
    Captures
  • 11
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    4,416
    • Citation Indexes
      4,410
    • Patent Family Citations
      5
      • Patent Families
        5
    • Policy Citations
      1
      • Policy Citation
        1
  • Captures
    4,827
  • Mentions
    11
    • References
      5
      • Wikipedia
        5
    • Blog Mentions
      3
      • Blog
        3
    • News Mentions
      3
      • News
        3

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Review Description

MicroRNAs (miRNAs) are small non-coding RNAs that function as guide molecules in RNA silencing. Targeting most protein-coding transcripts, miRNAs are involved in nearly all developmental and pathological processes in animals. The biogenesis of miRNAs is under tight temporal and spatial control, and their dysregulation is associated with many human diseases, particularly cancer. In animals, miRNAs are ∼22 nucleotides in length, and they are produced by two RNase III proteins-Drosha and Dicer. miRNA biogenesis is regulated at multiple levels, including at the level of miRNA transcription; its processing by Drosha and Dicer in the nucleus and cytoplasm, respectively; its modification by RNA editing, RNA methylation, uridylation and adenylation; Argonaute loading; and RNA decay. Non-canonical pathways for miRNA biogenesis, including those that are independent of Drosha or Dicer, are also emerging. © 2014 Macmillan Publishers Limited.

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