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Understanding HIV-1 latency provides clues for the eradication of long-term reservoirs

Nature Reviews Microbiology, ISSN: 1740-1526, Vol: 7, Issue: 11, Page: 798-812
2009
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Research In Viral Eradication of HIV Reservoirs; RIVER

STUDY INFORMATION OFFICIAL TITLE: Research In Viral Eradication of HIV Reservoirs CURRENT STATUS: Active, not recruiting STUDY TYPE: Interventional SPONSOR AGENCY:Imperial College LondonCLASS:Other COLLABORATOR AGENCY:Medical

Review Description

HIV-1 can infect both activated and resting, non-dividing cells, following which the viral genome can be permanently integrated into a host cell chromosome. Latent HIV-1 reservoirs are established early during primary infection and constitute a major barrier to eradication, even in the presence of highly active antiretroviral therapy. This Review analyses the molecular mechanisms that are necessary for the establishment of HIV-1 latency and their relationships with different cellular and anatomical reservoirs, and discusses the current treatment strategies for targeting viral persistence in reservoirs, their main limitations and future perspectives.

Bibliographic Details

Coiras, Mayte; López-Huertas, María Rosa; Pérez-Olmeda, Mayte; Alcamí, José

Springer Science and Business Media LLC

Immunology and Microbiology; Medicine

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