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A closed conformation for the Pol λ catalytic cycle

Nature Structural and Molecular Biology, ISSN: 1545-9993, Vol: 12, Issue: 1, Page: 97-98
2005
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Article Description

Pol λ is a family X member believed to fill short gaps during DNA repair. Here we report crystal structures of Pol λ representing three steps in filling a single-nucleotide gap. These structures indicate that, unlike other DNA polymerases, Pol λ does not undergo large subdomain movements during catalysis, and they provide a clear characterization of the geometry and stereochemistry of the in-line nucleotidyl transfer reaction.

Bibliographic Details

Garcia-Diaz, Miguel; Bebenek, Katarzyna; Krahn, Joseph M; Kunkel, Thomas A; Pedersen, Lars C

Springer Science and Business Media LLC

Biochemistry, Genetics and Molecular Biology

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