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Association between maternal hypertension and infant neurodevelopment in extremely preterm infants

Journal of Perinatology, ISSN: 1476-5543, Vol: 44, Issue: 4, Page: 539-547
2024
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  • Captures
    7
  • Social Media
    6
    • Shares, Likes & Comments
      6
      • Facebook
        6

Article Description

Objective: To examine the association between maternal hypertension during pregnancy and neurodevelopmental impairment (NDI) at 24 months post-menstrual age in extremely preterm infants. Study design: Using data from two tertiary neonatal units (2011–2017) for infants born at 23 + 0 to 28 + 6 weeks, we investigated outcomes of NDI related to maternal hypertension and small-for-gestational-age (SGA) status. Results: Of 1019 pre-term infants, 647 had complete data and were included in the analysis. Ninety-six (15%) had maternal hypertension exposure; 25 (4%) were also SGA. Infants with maternal hypertension showed a higher odds of any NDI (aOR: 2.29, 95% CI = 1.36–3.87) and significant NDI (aOR: 2.01, 95% CI = 1.02–3.95). The combination of hypertension and SGA further elevated this risk (aOR for any NDI: 4.88, 95% CI = 1.80–13.22; significant NDI: 6.91, 95% CI = 2.50–19.12). Conclusion: Maternal hypertension during pregnancy elevates the risk of NDI in extremely preterm infants, more so when combined with SGA.

Bibliographic Details

Abdelmageed, Wael A; Lapointe, Anie; Brown, Richard; Gorgos, Andreea; Luu, Thuy Mai; Beltempo, Marc; Altit, Gabriel; Dayan, Natalie

Springer Science and Business Media LLC

Medicine

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