The hypoglycemic mechanism of catalpol involves increased AMPK-mediated mitochondrial biogenesis
Acta Pharmacologica Sinica, ISSN: 1745-7254, Vol: 41, Issue: 6, Page: 791-799
2020
- 35Citations
- 30Captures
- 1Mentions
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- Citations35
- Citation Indexes35
- 35
- CrossRef15
- Captures30
- Readers30
- 30
- Mentions1
- News Mentions1
- News1
Most Recent News
The Active Ingredient Catalpol in Rehmannia glutinosa Reduces Blood Glucose in Diabetic Rats via the AMPK Pathway
Introduction Type 2 diabetes mellitus (T2DM), known as a chronic metabolic disease, is showing a rapidly rising epidemic worldwide.1,2 According to the latest statistics, 537
Article Description
Mitochondria serve as sensors of energy regulation and glucose levels, which are impaired by diabetes progression. Catalpol is an iridoid glycoside that exerts a hypoglycemic effect by improving mitochondrial function, but the underlying mechanism has not been fully elucidated. In the current study we explored the effects of catalpol on mitochondrial function in db/db mice and C2C12 myotubes in vitro. After oral administration of catalpol (200 mg·kg·d) for 8 weeks, db/db mice exhibited a decreased fasting blood glucose level and restored mitochondrial function in skeletal muscle. Catalpol increased mitochondrial biogenesis, evidenced by significant elevations in the number of mitochondria, mitochondrial DNA levels, and the expression of three genes associated with mitochondrial biogenesis: peroxisome proliferator-activated receptor gammaco-activator 1 (PGC-1α), mitochondrial transcription factor A (TFAM) and nuclear respiratory factor 1 (NRF1). In C2C12 myotubes, catalpol significantly increased glucose uptake and ATP production. These effects depended on activation of AMP-activated protein kinase (AMPK)-mediated mitochondrial biogenesis. Thus, catalpol improves skeletal muscle mitochondrial function by activating AMPK-mediated mitochondrial biogenesis. These findings may guide the development of a new therapeutic approach for type 2 diabetes.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85077871285&origin=inward; http://dx.doi.org/10.1038/s41401-019-0345-2; http://www.ncbi.nlm.nih.gov/pubmed/31937931; https://www.nature.com/articles/s41401-019-0345-2; http://sciencechina.cn/gw.jsp?action=cited_outline.jsp&type=1&id=6727080&internal_id=6727080&from=elsevier; https://dx.doi.org/10.1038/s41401-019-0345-2
Springer Science and Business Media LLC
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