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Adherence to the World Cancer Research Fund/American Institute for Cancer Research cancer prevention recommendations throughout the life course and risk of colorectal cancer precursors

British Journal of Cancer, ISSN: 1532-1827, Vol: 128, Issue: 12, Page: 2243-2252
2023
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Metric Options:   Counts1 Year3 Year

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Article Description

Background: Despite the increasing incidence in colorectal cancer (CRC) among the young population, the involvement of modifiable early-life exposures is understudied. Methods: We prospectively investigated the association of lifestyle score, which measures adherence to the 2018 World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) cancer prevention recommendations, in adolescence and adulthood with risk of CRC precursors in 34,509 women enrolled in the Nurses’ Health Study II. Participants reported adolescent diet in 1998 and subsequently underwent at least one lower gastrointestinal endoscopy between 1999 and 2015. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using multivariable logistic regression for clustered data. Results: During follow-up (1998–2015), 3036 women had at least one adenoma, and 2660 had at least one serrated lesion. In multivariable analysis, per unit increase in adolescent WCRF/AICR lifestyle score was not associated with risk of total adenoma or serrated lesions, in contrast to adult WCRF/AICR lifestyle score (OR = 0.92, 95% CI: 0.87–0.97, P = 0.002 for total adenoma; and OR = 0.86, 95% CI: 0.81–0.92, P < 0.001 for total serrated lesions). Conclusion: Adherence to the 2018 WCRF/AICR recommendations during adulthood but not during adolescence was associated with a lower risk of CRC precursors.

Bibliographic Details

Zhang, Shuqi; Hur, Jinhee; Song, Rui; Wang, Peilu; Cao, Yin; Wu, Kana; Giovannucci, Edward

Springer Science and Business Media LLC

Medicine; Biochemistry, Genetics and Molecular Biology

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