Epigenetic mechanisms of Strip2 in differentiation of pluripotent stem cells
Cell Death Discovery, ISSN: 2058-7716, Vol: 8, Issue: 1, Page: 447
2022
- 4Citations
- 2Captures
- 1Mentions
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- Citations4
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Most Recent News
Faculty of Medicine and University Hospital Cologne Researchers Report on Findings in Embryonic Stem Cells (Epigenetic mechanisms of Strip2 in differentiation of pluripotent stem cells)
2022 NOV 17 (NewsRx) -- By a News Reporter-Staff News Editor at Stem Cell Daily -- Data detailed on embryonic stem cells have been presented.
Article Description
Significant evidence points to Strip2 being a key regulator of the differentiation processes of pluripotent embryonic stem cells. However, Strip2 mediated epigenetic regulation of embryonic differentiation and development is quite unknown. Here, we identified several interaction partners of Strip2, importantly the co-repressor molecular protein complex nucleosome remodeling deacetylase/Tripartite motif-containing 28/Histone deacetylases/Histone-lysine N-methyltransferase SETDB1 (NuRD/TRIM28/HDACs/SETDB1) histone methyltransferase, which is primarily involved in regulation of the pluripotency of embryonic stem cells and its differentiation. The complex is normally activated by binding of Krueppel-associated box zinc-finger proteins (KRAB-ZFPs) to specific DNA motifs, causing methylation of H3 to Lysin-9 residues (H3K9). Our data showed that Strip2 binds to a DNA motif (20 base pairs), like the KRAB-ZFPs. We establish that Strip2 is an epigenetic regulator of pluripotency and differentiation by modulating DNA KRAB-ZFPs as well as the NuRD/TRIM28/HDACs/SETDB1 histone methyltransferase complex.
Bibliographic Details
Springer Science and Business Media LLC
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