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Massiliamide, a cyclic tetrapeptide with potent tyrosinase inhibitory properties from the Gram-negative bacterium Massilia albidiflava DSM 17472

Journal of Antibiotics, ISSN: 1881-1469, Vol: 74, Issue: 4, Page: 269-272
2021
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Article Description

A cyclic tetrapeptide, designated massiliamide, was isolated from the liquid culture of the Gram-negative bacterium Massilia albidiflava DSM 17472. The structure was elucidated through extensive spectroscopic analysis, including HR-MS and 1D and 2D NMR experiments. The absolute configuration was determined using the Marfey´s method. Massiliamide showed potent inhibitory activity towards tyrosinase with an IC value of 1.15 µM and no cytotoxicity.

Bibliographic Details

Frediansyah, Andri; Straetener, Jan; Brötz-Oesterhelt, Heike; Gross, Harald

Springer Science and Business Media LLC

Pharmacology, Toxicology and Pharmaceutics

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