Low-frequency variation in TP53 has large effects on head circumference and intracranial volume
Nature Communications, ISSN: 2041-1723, Vol: 10, Issue: 1, Page: 357
2019
- 23Citations
- 104Captures
- 3Mentions
Metric Options: Counts1 Year3 YearSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations23
- Citation Indexes23
- CrossRef23
- Captures104
- Readers104
- 104
- Mentions3
- News Mentions2
- 2
- Blog Mentions1
- 1
Most Recent Blog
Heritable genetic variants in key cancer genes link cancer risk with anthropometric traits
Article Text Article menu Article Text Article info Citation Tools Share Responses Article metrics Alerts PDF Complex traits Original research Heritable genetic variants in key
Most Recent News
Genes with Large Effect on Head and Brain Size Discovered
Researchers report genetic influences on head circumference remain stable during development and are correlated with genetic factors which contribute to intracranial volume.
Article Description
Cranial growth and development is a complex process which affects the closely related traits of head circumference (HC) and intracranial volume (ICV). The underlying genetic influences shaping these traits during the transition from childhood to adulthood are little understood, but might include both age-specific genetic factors and low-frequency genetic variation. Here, we model the developmental genetic architecture of HC, showing this is genetically stable and correlated with genetic determinants of ICV. Investigating up to 46,000 children and adults of European descent, we identify association with final HC and/or final ICV + HC at 9 novel common and low-frequency loci, illustrating that genetic variation from a wide allele frequency spectrum contributes to cranial growth. The largest effects are reported for low-frequency variants within TP53, with 0.5 cm wider heads in increaser-allele carriers versus non-carriers during mid-childhood, suggesting a previously unrecognized role of TP53 transcripts in human cranial development.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85060231664&origin=inward; http://dx.doi.org/10.1038/s41467-018-07863-x; http://www.ncbi.nlm.nih.gov/pubmed/30664637; https://www.nature.com/articles/s41467-018-07863-x; https://dx.doi.org/10.1038/s41467-018-07863-x; http://research-repository.uwa.edu.au/en/publications/lowfrequency-variation-in-tp53-has-large-effects-on-head-circumference-and-intracranial-volume(e2fcdf9b-cab6-4e1e-bdbd-efbfd6061737).html; https://research-repository.uwa.edu.au/en/publications/low-frequency-variation-in-tp53-has-large-effects-on-head-circumf; https://research-repository.uwa.edu.au/en/publications/lowfrequency-variation-in-tp53-has-large-effects-on-head-circumference-and-intracranial-volume(e2fcdf9b-cab6-4e1e-bdbd-efbfd6061737).html
Springer Science and Business Media LLC
Provide Feedback
Have ideas for a new metric? Would you like to see something else here?Let us know