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Sustained elevation of MG53 in the bloodstream increases tissue regenerative capacity without compromising metabolic function

Nature Communications, ISSN: 2041-1723, Vol: 10, Issue: 1, Page: 4659
2019
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Advances in the Study of MG53 in Cardiovascular Disease

Introduction Cardiovascular disease, a broad term encompassing conditions affecting the heart and blood vessels, is closely linked to both metabolic and lifestyle risk factors. These

Article Description

MG53 is a muscle-specific TRIM-family protein that presides over the cell membrane repair response. Here, we show that MG53 present in blood circulation acts as a myokine to facilitate tissue injury-repair and regeneration. Transgenic mice with sustained elevation of MG53 in the bloodstream (tPA-MG53) have a healthier and longer life-span when compared with littermate wild type mice. The tPA-MG53 mice show normal glucose handling and insulin signaling in skeletal muscle, and sustained elevation of MG53 in the bloodstream does not have a deleterious impact on db/db mice. More importantly, the tPA-MG53 mice display remarkable dermal wound healing capacity, enhanced muscle performance, and improved injury-repair and regeneration. Recombinant human MG53 protein protects against eccentric contraction-induced acute and chronic muscle injury in mice. Our findings highlight the myokine function of MG53 in tissue protection and present MG53 as an attractive biological reagent for regenerative medicine without interference with glucose handling in the body.

Bibliographic Details

Bian, Zehua; Wang, Qiang; Zhou, Xinyu; Tan, Tao; Park, Ki Ho; Kramer, H Fritz; McDougal, Alan; Laping, Nicholas J; Kumar, Sanjay; Adesanya, T M Ayodele; Sermersheim, Matthew; Yi, Frank; Wang, Xinxin; Wu, Junwei; Gumpper, Kristyn; Jiang, Qiwei; He, Duofen; Lin, Pei-Hui; Li, Haichang; Guan, Fangxia; Zhou, Jingsong; Kohr, Mark J; Zeng, Chunyu; Zhu, Hua; Ma, Jianjie

Springer Science and Business Media LLC

Chemistry; Biochemistry, Genetics and Molecular Biology; Physics and Astronomy

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