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Insights into malaria susceptibility using genome-wide data on 17,000 individuals from Africa, Asia and Oceania

Nature Communications, ISSN: 2041-1723, Vol: 10, Issue: 1, Page: 5732
2019
  • 108
    Citations
  • 0
    Usage
  • 196
    Captures
  • 1
    Mentions
  • 15
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    108
  • Captures
    196
  • Mentions
    1
    • News Mentions
      1
      • 1
  • Social Media
    15
    • Shares, Likes & Comments
      15
      • Facebook
        15

Most Recent News

New insights into our multi-millenia battle with malaria

Humans have long been thwarted by 'the fever'. References to malaria's infamous febricity are found across antiquity, from writings by the four thousand-year-old Vedic sages of ancient India to the Greek physician Hippocrates. But the disease, caused by a group of parasites belonging to the Plasmodium genus, has troubled our ancestors and close relatives for much longer. A range of malaria species

Article Description

The human genetic factors that affect resistance to infectious disease are poorly understood. Here we report a genome-wide association study in 17,000 severe malaria cases and population controls from 11 countries, informed by sequencing of family trios and by direct typing of candidate loci in an additional 15,000 samples. We identify five replicable associations with genome-wide levels of evidence including a newly implicated variant on chromosome 6. Jointly, these variants account for around one-tenth of the heritability of severe malaria, which we estimate as ~23% using genome-wide genotypes. We interrogate available functional data and discover an erythroid-specific transcription start site underlying the known association in ATP2B4, but are unable to identify a likely causal mechanism at the chromosome 6 locus. Previously reported HLA associations do not replicate in these samples. This large dataset will provide a foundation for further research on thegenetic determinants of malaria resistance in diverse populations.

Bibliographic Details

Gavin Band; Quang Si Le; Geraldine M. Clarke; Katja Kivinen; Christina Hubbart; Anna E. Jeffreys; Kate Rowlands; Ellen M. Leffler; Muminatou Jallow; David J. Conway; Fatoumatta Sisay-Joof; Giorgio Sirugo; Umberto d’Alessandro; Ousmane B. Toure; Mahamadou A. Thera; Salimata Konate; Sibiri Sissoko; Valentina D. Mangano; Edith C. Bougouma; Sodiomon B. Sirima; Lucas N. Amenga-Etego; Anita K. Ghansah; Abraham V. O. Hodgson; Michael D. Wilson; Anthony Enimil; Daniel Ansong; Jennifer Evans; Subulade A. Ademola; Tobias O. Apinjoh; Carolyne M. Ndila; Alphaxard Manjurano; Chris Drakeley; Hugh Reyburn; Nguyen Hoan Phu; Nguyen Thi Ngoc Quyen; Cao Quang Thai; Tran Tinh Hien; Yik Ying Teo; Laurens Manning; Moses Laman; Pascal Michon; Harin Karunajeewa; Peter Siba; Steve Allen; Angela Allen; Melanie Bahlo; Timothy M. E. Davis; Victoria Simpson; Jennifer Shelton; Chris C. A. Spencer; George B. J. Busby; Angeliki Kerasidou; Eleanor Drury; Jim Stalker; Alexander Dilthey; Alexander J. Mentzer; Gil McVean; Kalifa A. Bojang; Ogobara Doumbo; David Modiano; Kwadwo A. Koram; Tsiri Agbenyega; Olukemi K. Amodu; Eric Achidi; Thomas N. Williams; Kevin Marsh; Eleanor M. Riley; Malcolm Molyneux; Terrie Taylor; Sarah J. Dunstan; Jeremy Farrar; Ivo Mueller; Kirk A. Rockett; Dominic P. Kwiatkowski

Springer Science and Business Media LLC

Chemistry; Biochemistry, Genetics and Molecular Biology; Physics and Astronomy

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