GPR56/ADGRG1 is associated with response to antidepressant treatment
Nature Communications, ISSN: 2041-1723, Vol: 11, Issue: 1, Page: 1635
2020
- 42Citations
- 146Captures
- 10Mentions
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations42
- Citation Indexes42
- 42
- CrossRef38
- Captures146
- Readers146
- 146
- Mentions10
- News Mentions7
- News7
- References2
- Wikipedia2
- Blog Mentions1
- Blog1
Most Recent Blog
Key protein involved in the biology of depression identified
The GPR56 protein has been implicated in the biology of depression and a person's response to antidepressants.
Most Recent News
McGill University: Promising Advance in Depression Research
McGill University issued the following news release: * * * - Identification of key protein may lead to more effective anti-depressants * * * Depression
Article Description
It remains unclear why many patients with depression do not respond to antidepressant treatment. In three cohorts of individuals with depression and treated with serotonin-norepinephrine reuptake inhibitor (N = 424) we show that responders, but not non-responders, display an increase of GPR56 mRNA in the blood. In a small group of subjects we also show that GPR56 is downregulated in the PFC of individuals with depression that died by suicide. In mice, we show that chronic stress-induced Gpr56 downregulation in the blood and prefrontal cortex (PFC), which is accompanied by depression-like behavior, and can be reversed by antidepressant treatment. Gpr56 knockdown in mouse PFC is associated with depressive-like behaviors, executive dysfunction and poor response to antidepressant treatment. GPR56 peptide agonists have antidepressant-like effects and upregulated AKT/GSK3/EIF4 pathways. Our findings uncover a potential role of GPR56 in antidepressant response.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85082980283&origin=inward; http://dx.doi.org/10.1038/s41467-020-15423-5; http://www.ncbi.nlm.nih.gov/pubmed/32242018; https://clinicaltrials.gov/ct2/show/NCT00635219; https://www.nature.com/articles/s41467-020-15423-5; https://dx.doi.org/10.1038/s41467-020-15423-5
Springer Science and Business Media LLC
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