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Protection of COVID-19 vaccination and previous infection against Omicron BA.1, BA.2 and Delta SARS-CoV-2 infections

Nature Communications, ISSN: 2041-1723, Vol: 13, Issue: 1, Page: 4738
2022
  • 95
    Citations
  • 0
    Usage
  • 63
    Captures
  • 2
    Mentions
  • 13
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    95
  • Captures
    63
  • Mentions
    2
    • News Mentions
      2
      • News
        2
  • Social Media
    13
    • Shares, Likes & Comments
      13
      • Facebook
        13

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Article Description

Given the emergence of the SARS-CoV-2 Omicron BA.1 and BA.2 variants and the roll-out of booster COVID-19 vaccination, evidence is needed on protection conferred by primary vaccination, booster vaccination and previous SARS-CoV-2 infection by variant. We employed a test-negative design on S-gene target failure data from community PCR testing in the Netherlands from 22 November 2021 to 31 March 2022 (n = 671,763). Previous infection, primary vaccination or both protected well against Delta infection. Protection against Omicron BA.1 infection was much lower compared to Delta. Protection was similar against Omicron BA.1 compared to BA.2 infection after previous infection, primary and booster vaccination. Higher protection was observed against all variants in individuals with both vaccination and previous infection compared with either one. Protection against all variants decreased over time since last vaccination or infection. We found that primary vaccination with current COVID-19 vaccines and previous SARS-CoV-2 infections offered low protection against Omicron BA.1 and BA.2 infection. Booster vaccination considerably increased protection against Omicron infection, but decreased rapidly after vaccination.

Bibliographic Details

Andeweg, Stijn P; de Gier, Brechje; Eggink, Dirk; van den Ende, Caroline; van Maarseveen, Noortje; Ali, Lubna; Vlaemynck, Boris; Schepers, Raf; Hahné, Susan J M; Reusken, Chantal B E M; de Melker, Hester E; van den Hof, Susan; Knol, Mirjam J

Springer Science and Business Media LLC

Chemistry; Biochemistry, Genetics and Molecular Biology; Physics and Astronomy

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