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Photoredox cooperative N-heterocyclic carbene/palladium-catalysed alkylacylation of alkenes

Nature Communications, ISSN: 2041-1723, Vol: 13, Issue: 1, Page: 5754
2022
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New Science Study Findings Have Been Reported from Chinese Academy of Sciences (Photoredox Cooperative N-heterocyclic Carbene/palladium-catalysed Alkylacylation of Alkenes)

2022 NOV 04 (NewsRx) -- By a News Reporter-Staff News Editor at Chemicals & Chemistry Daily Daily -- A new study on Science is now

Article Description

Three-component carboacylation of simple alkenes with readily available reagents is challenging. Transition metal-catalysed intermolecular carboacylation works for alkenes with strained ring or directing groups. Herein, we develop a photoredox cooperative N-heterocyclic carbene/Pd-catalysed alkylacylation of simple alkenes with aldehydes and unactivated alkyl halides to provide ketones in good yields. This multicomponent coupling reaction features a wide scope of alkenes, broad functional group compatibility and free of exogenous photosensitizer or external reductant. In addition, a series of chlorinated cyclopropanes with one or two vicinal quaternary carbons is obtained when chloroform or carbon tetrachloride is used as the alkyl halide. The reaction involves the alkyl radicals from halides and the ketyl radicals from aldehydes under photoredox cooperative N-heterocyclic carbene/Pd catalysis.

Bibliographic Details

Han, You-Feng; Huang, Ying; Liu, Hao; Gao, Zhong-Hua; Zhang, Chun-Lin; Ye, Song

Springer Science and Business Media LLC

Chemistry; Biochemistry, Genetics and Molecular Biology; Physics and Astronomy

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