Stereoisomeric engineering of aggregation-induced emission photosensitizers towards fungal killing
Nature Communications, ISSN: 2041-1723, Vol: 13, Issue: 1, Page: 7046
2022
- 43Citations
- 18Captures
- 1Mentions
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations43
- Citation Indexes43
- 43
- CrossRef14
- Captures18
- Readers18
- 18
- Mentions1
- News Mentions1
- News1
Most Recent News
Guangzhou Medical University Reports Findings in Supramolecular Research (Stereoisomeric engineering of aggregation-induced emission photosensitizers towards fungal killing)
2022 DEC 02 (NewsRx) -- By a News Reporter-Staff News Editor at Nanotech Daily -- New research on Nanotechnology - Supramolecular Research is the subject
Article Description
Fungal infection poses and increased risk to human health. Photodynamic therapy (PDT) as an alternative antifungal approach garners much interest due to its minimal side effects and negligible antifungal drug resistance. Herein, we develop stereoisomeric photosensitizers ((Z)- and (E)-TPE-EPy) by harnessing different spatial configurations of one molecule. They possess aggregation-induced emission characteristics and ROS, viz. O and O generation capabilities that enable image-guided PDT. Also, the cationization of the photosensitizers realizes the targeting of fungal mitochondria for antifungal PDT killing. Particularly, stereoisomeric engineering assisted by supramolecular assembly leads to enhanced fluorescence intensity and ROS generation efficiency of the stereoisomers due to the excited state energy flow from nonradiative decay to the fluorescence pathway and intersystem (ISC) process. As a result, the supramolecular assemblies based on (Z)- and (E)-TPE-EPy show dramatically lowered dark toxicity without sacrificing their significant phototoxicity in the photodynamic antifungal experiments. This study is a demonstration of stereoisomeric engineering of aggregation-induced emission photosensitizers based on (Z)- and (E)-configurations.
Bibliographic Details
Springer Science and Business Media LLC
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