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Delayed generation of functional virus-specific circulating T follicular helper cells correlates with severe COVID-19

Nature Communications, ISSN: 2041-1723, Vol: 14, Issue: 1, Page: 2164
2023
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Karolinska Institute Researchers Release New Study Findings on COVID-19 (Delayed generation of functional virus-specific circulating T follicular helper cells correlates with severe COVID-19)

2023 APR 27 (NewsRx) -- By a News Reporter-Staff News Editor at NewsRx COVID-19 Daily -- Researchers detail new data in COVID-19. According to news

Article Description

Effective humoral immune responses require well-orchestrated B and T follicular helper (Tfh) cell interactions. Whether these interactions are impaired and associated with COVID-19 disease severity is unclear. Here, longitudinal blood samples across COVID-19 disease severity are analysed. We find that during acute infection SARS-CoV-2-specific circulating Tfh (cTfh) cells expand with disease severity. SARS-CoV-2-specific cTfh cell frequencies correlate with plasmablast frequencies and SARS-CoV-2 antibody titers, avidity and neutralization. Furthermore, cTfh cells but not other memory CD4 T cells, from severe patients better induce plasmablast differentiation and antibody production compared to cTfh cells from mild patients. However, virus-specific cTfh cell development is delayed in patients that display or later develop severe disease compared to those with mild disease, which correlates with delayed induction of high-avidity neutralizing antibodies. Our study suggests that impaired generation of functional virus-specific cTfh cells delays high-quality antibody production at an early stage, potentially enabling progression to severe disease.

Bibliographic Details

Yu, Meng; Charles, Afandi; Cagigi, Alberto; Christ, Wanda; Österberg, Björn; Falck-Jones, Sara; Azizmohammadi, Lida; Åhlberg, Eric; Falck-Jones, Ryan; Svensson, Julia; Nie, Mu; Warnqvist, Anna; Hellgren, Fredrika; Lenart, Klara; Arcoverde Cerveira, Rodrigo; Ols, Sebastian; Lindgren, Gustaf; Lin, Ang; Maecker, Holden; Bell, Max; Johansson, Niclas; Albert, Jan; Sundling, Christopher; Czarnewski, Paulo; Klingström, Jonas; Färnert, Anna; Loré, Karin; Smed-Sörensen, Anna

Springer Science and Business Media LLC

Chemistry; Biochemistry, Genetics and Molecular Biology; Physics and Astronomy

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