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Resurgence of Omicron BA.2 in SARS-CoV-2 infection-naive Hong Kong

Nature Communications, ISSN: 2041-1723, Vol: 14, Issue: 1, Page: 2422
2023
  • 14
    Citations
  • 0
    Usage
  • 15
    Captures
  • 3
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    14
  • Captures
    15
  • Mentions
    3
    • News Mentions
      2
      • News
        2
    • Blog Mentions
      1
      • Blog
        1

Most Recent News

University of Hong Kong Reports Findings in COVID-19 (Resurgence of Omicron BA.2 in SARS-CoV-2 infection-naive Hong Kong)

2023 MAY 09 (NewsRx) -- By a News Reporter-Staff News Editor at NewsRx COVID-19 Daily -- New research on Coronavirus - COVID-19 is the subject

Article Description

Hong Kong experienced a surge of Omicron BA.2 infections in early 2022, resulting in one of the highest per-capita death rates of COVID-19. The outbreak occurred in a dense population with low immunity towards natural SARS-CoV-2 infection, high vaccine hesitancy in vulnerable populations, comprehensive disease surveillance and the capacity for stringent public health and social measures (PHSMs). By analyzing genome sequences and epidemiological data, we reconstructed the epidemic trajectory of BA.2 wave and found that the initial BA.2 community transmission emerged from cross-infection within hotel quarantine. The rapid implementation of PHSMs suppressed early epidemic growth but the effective reproduction number (R) increased again during the Spring festival in early February and remained around 1 until early April. Independent estimates of point prevalence and incidence using phylodynamics also showed extensive superspreading at this time, which likely contributed to the rapid expansion of the epidemic. Discordant inferences based on genomic and epidemiological data underscore the need for research to improve near real-time epidemic growth estimates by combining multiple disparate data sources to better inform outbreak response policy.

Bibliographic Details

Xie, Ruopeng; Edwards, Kimberly M; Adam, Dillon C; Leung, Kathy S M; Tsang, Tim K; Gurung, Shreya; Xiong, Weijia; Wei, Xiaoman; Ng, Daisy Y M; Liu, Gigi Y Z; Krishnan, Pavithra; Chang, Lydia D J; Cheng, Samuel M S; Gu, Haogao; Siu, Gilman K H; Wu, Joseph T; Leung, Gabriel M; Peiris, Malik; Cowling, Benjamin J; Poon, Leo L M; Dhanasekaran, Vijaykrishna

Springer Science and Business Media LLC

Chemistry; Biochemistry, Genetics and Molecular Biology; Physics and Astronomy

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