Defining diurnal fluctuations in mouse choroid plexus and CSF at high molecular, spatial, and temporal resolution
Nature Communications, ISSN: 2041-1723, Vol: 14, Issue: 1, Page: 3720
2023
- 15Citations
- 28Usage
- 55Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations15
- Citation Indexes15
- 15
- Usage28
- Downloads21
- Abstract Views7
- Captures55
- Readers55
- 55
Article Description
Transmission and secretion of signals via the choroid plexus (ChP) brain barrier can modulate brain states via regulation of cerebrospinal fluid (CSF) composition. Here, we developed a platform to analyze diurnal variations in male mouse ChP and CSF. Ribosome profiling of ChP epithelial cells revealed diurnal translatome differences in metabolic machinery, secreted proteins, and barrier components. Using ChP and CSF metabolomics and blood-CSF barrier analyses, we observed diurnal changes in metabolites and cellular junctions. We then focused on transthyretin (TTR), a diurnally regulated thyroid hormone chaperone secreted by the ChP. Diurnal variation in ChP TTR depended on Bmal1 clock gene expression. We achieved real-time tracking of CSF-TTR in awake Ttr mice via multi-day intracerebroventricular fiber photometry. Diurnal changes in ChP and CSF TTR levels correlated with CSF thyroid hormone levels. These datasets highlight an integrated platform for investigating diurnal control of brain states by the ChP and CSF.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85162757887&origin=inward; http://dx.doi.org/10.1038/s41467-023-39326-3; http://www.ncbi.nlm.nih.gov/pubmed/37349305; https://www.nature.com/articles/s41467-023-39326-3; https://digitalcommons.wustl.edu/oa_4/2122; https://digitalcommons.wustl.edu/cgi/viewcontent.cgi?article=3108&context=oa_4; https://dx.doi.org/10.1038/s41467-023-39326-3
Springer Science and Business Media LLC
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