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C. elegans ageing is accelerated by a self-destructive reproductive programme

Nature Communications, ISSN: 2041-1723, Vol: 14, Issue: 1, Page: 4381
2023
  • 11
    Citations
  • 0
    Usage
  • 30
    Captures
  • 5
    Mentions
  • 16
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    11
  • Captures
    30
  • Mentions
    5
    • News Mentions
      5
      • 5
  • Social Media
    16
    • Shares, Likes & Comments
      16
      • Facebook
        16

Most Recent News

Lifespan of Ageing Model Organism Driven by Reproductive Self-Destruction

Top Image: Questions raised about how well insights from C. elegans can translate to larger organism ageing The lifespan of a small roundworm that has

Article Description

In post-reproductive C. elegans, destructive somatic biomass repurposing supports production of yolk which, it was recently shown, is vented and can serve as a foodstuff for larval progeny. This is reminiscent of the suicidal reproductive effort (reproductive death) typical of semelparous organisms such as Pacific salmon. To explore the possibility that C. elegans exhibits reproductive death, we have compared sibling species pairs of the genera Caenorhabditis and Pristionchus with hermaphrodites and females. We report that yolk venting and constitutive, early pathology involving major anatomical changes occur only in hermaphrodites, which are also shorter lived. Moreover, only in hermaphrodites does germline removal suppress senescent pathology and markedly increase lifespan. This is consistent with the hypothesis that C. elegans exhibit reproductive death that is suppressed by germline ablation. If correct, this would imply a major difference in the ageing process between C. elegans and most higher organisms, and potentially explain the exceptional plasticity in C. elegans ageing.

Bibliographic Details

Kern, Carina C; Srivastava, Shivangi; Ezcurra, Marina; Hsiung, Kuei Ching; Hui, Nancy; Townsend, StJohn; Maczik, Dominik; Zhang, Bruce; Tse, Victoria; Konstantellos, Viktoras; Bähler, Jürg; Gems, David

Springer Science and Business Media LLC

Chemistry; Biochemistry, Genetics and Molecular Biology; Physics and Astronomy

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