Fate specification is spatially intermingled across planarian stem cells
Nature Communications, ISSN: 2041-1723, Vol: 14, Issue: 1, Page: 7422
2023
- 9Citations
- 17Captures
- 1Mentions
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations9
- Citation Indexes9
- Captures17
- Readers17
- 17
- Mentions1
- News Mentions1
- News1
Most Recent News
CELL FATE CHOICE DURING ADULT REGENERATION IS HIGHLY DISORGANIZED, NEW STUDY FINDS
The following information was released by Whitehead Institute for Biomedical Research: Written by Nicole Davis November 27, 2023 A team of scientists at the Whitehead
Article Description
Regeneration requires mechanisms for producing a wide array of cell types. Neoblasts are stem cells in the planarian Schmidtea mediterranea that undergo fate specification to produce over 125 adult cell types. Fate specification in neoblasts can be regulated through expression of fate-specific transcription factors. We utilize multiplexed error-robust fluorescence in situ hybridization (MERFISH) and whole-mount FISH to characterize fate choice distribution of stem cells within planarians. Fate choices are often made distant from target tissues and in a highly intermingled manner, with neighboring neoblasts frequently making divergent fate choices for tissues of different location and function. We propose that pattern formation is driven primarily by the migratory assortment of progenitors from mixed and spatially distributed fate-specified stem cells and that fate choice involves stem-cell intrinsic processes.
Bibliographic Details
Springer Science and Business Media LLC
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